• br Funding This study was

  2018-10-23

  

  Funding This study was funded by a research grant from the French Ministry of Health (PHRC 2007, P071228) and sponsored by the Département de la Recherche Clinique et du Développement de l\'Assistance Publique–Hôpitaux de Paris. The Inserm unit 1134 and Institut National de la Transfusion Sanguin

• In this issue Uckun et al take the concept

  2018-10-23

  

  In this issue, Uckun et al. take the concept of SMaRT-mediated repair back to its roots and explore its use in the repair of an oncogenic defect, CD22ΔE12, in childhood B-precursor leukemia (BPL), the largest subset of B-lineage acute lymphoblastic leukemia (ALL) (). BPL xanthine oxidase express dys

• br Methods br Results A total of patients males

  2018-10-23

  

  Methods Results A total of 102 patients (69 males and 33 females, 70.1±9.2years) were registered in the study. Baseline clinical characteristics are presented in Table 1. Telomere G-tail length was negatively correlated with aging and positively correlated with total telomere length (ρ −0.287,

• Current therapies for the treatment of

  2018-10-23

  

  Current therapies for the treatment of HPV infection of the ano-genital tract are mainly ablative and devoted to the removal of damaged HPV-infected lesions, such as warts and squamous intraepithelial lesions (Krogh von et al., 2000). However, most patients are not featured by macroscopic lesions. I

• Finally we hypothesized that hepcidin concentrations might i

  2018-10-23

  

  Finally we hypothesized that hepcidin concentrations might influence the subsequent risk of malaria. Intriguing data from mouse studies suggest that hepcidin might play a role in modulating clinical malaria (Wang et al., 2011; Portugal et al., 2011), but we are not aware of any previous studies that

• We have shown that long term WL CR modulates adipocyte

  2018-10-23

  

  We have shown that long-term WL/CR modulates adipocyte differentiation of ASCs in human sWAT by inducing both positive and negative regulators of the IGF-1 system at early stages of adipogenesis. Importantly, we identified DIRAS3 as novel negative regulator of adipogenesis, which slows down this pro

• On the basis of our genetic findings that hexokinase HK

  2018-10-23

  

  On the basis of our genetic findings that hexokinase 2 (HK2)-mediated aerobic glycolysis, known as the Warburg effect, drives prostate tumor growth in xenograft model bearing /p53-deficient murine or human prostate cancer igf1r inhibitor (Wang et al., 2014), we designed preclinical studies to deter

• M tuberculosis has been considered innately resistant to lac

  2018-10-23

  

  M. tuberculosis has been considered innately resistant to β-lactam antibiotics, due to β–lactamase activity and the presence of non-classical transpeptidases in their cell wall (Hugonnet et al., 2009; Gupta et al., 2010). M. tuberculosis possesses a highly active β-lactamase, BlaC, that rapidly hydr

• br Materials and Methods br

  2018-10-23

  

  Materials and Methods Results Discussion The thoracic aortic aneurysm in BAV patients frequently involves ascending aorta, where the SMCs are derived from the neural crest. In contrast, patients with BAV rarely have aneurysms involving the descending thoracic aorta, and the SMCs in this reg

• Given this background the study of

  2018-10-23

  

  Given this background, the study of Scherer et al. reported in this issue () is of considerable interest, because it provides the first in-depth analysis of the change in the VLP/virion antibody repertoire in individual women who were naturally infected by HPV, and who are then vaccinated with VLPs.

• br Funding Sources Support for this project was provided

  2018-10-23

  

  Funding Sources Support for this project was provided to A.J.M. through grants from Susan G. Komen for the Cure,KG110601 and the Pennsylvania Department of Health, SAP #4100068718. G.C.P. and A.J.M. also receive financial support from NIH grants CA159337 and CA159315. No funding sources including

• IDO small molecule inhibitors are

  2018-10-23

  

  IDO1 small molecule inhibitors are currently being evaluated in clinical trials for a variety of cancers based on the supposition that they will help to enable an effective immune response directed against the tumor. This study indicates, however, that a more complex conceptualization of how the tum

• Diagnosis of ZIKV infection is performed

  2018-10-23

  

  Diagnosis of ZIKV infection is performed through detection of viral components (e.g., viral RNA, viral proteins, or virus isolation) and detection of host immune response (e.g., daunorubicin against viral proteins). For viral component-based diagnosis, RT-PCR, immunoassay, and virus isolation detec

• pde inhibitors Since WNK overexpression accelerated expressi

  2018-10-23

  

  Since WNK4 overexpression accelerated pde inhibitors of adipogenic genes (Fig. S7), we expected the overexpression of WNK4 in adipocytes would cause the phenotypes opposite to those in WNK4−/− mice. We first checked the WNK4 protein levels in the adipose tissues of WNK4D561A/+ and WNK4-Tg mice, whi

• br Protein molecular evolution analysis The protocol

  2018-10-23

  

  Protein molecular evolution analysis The protocol included new protein molecular evolution tests integrating patterns of nucleotide sequence similarities with protein tertiary structures. The MEGA program was used in calculations of codon usage statistics. Specifically, the ratios between observe

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