As a potential platform to model HD cellular pathogenesis an

2018-10-20

As a potential platform to model HD cellular pathogenesis, an important goal of this study was to assess whether our cellular model recapitulates disease-associated pathologic events. We found that an increase of intranuclear inclusions and the accumulation of oligomeric, soluble, and insoluble mHTT

It was recently shown that

2018-10-20

It was recently shown that hPSCs can be expanded as cell-only pterostilbene in serum-free suspension culture irrespective of matrix supplementation (Amit et al., 2011; Olmer et al., 2010; Singh et al., 2010), which is mandatory for conventional surface-attached propagation of hPSCs. In contrast to

A variety of suitable murine xenograft models are currently

2018-10-20

A variety of suitable murine xenograft models are currently used in hematopoietic research, yet these animals require conditioning prior to experimentation. Given the increasingly restricted access to radiation sources, NBSGW mice are broadly enabling, allowing laboratories without access to radiati

Although previous work showed that SOX is sufficient to conv

2018-10-20

Although previous work showed that SOX2 is sufficient to convert fibroblasts into NES+ multipotent NSCs under a unique culture condition (Ring et al., 2012), our genetic approach using Nes-CreER;Rosa-YFP mice failed to detect a stable NSC state during the in vivo reprogramming process. This differen

br Experimental Procedures br Author Contributions br

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Introduction Human embryonic stem cells (hESCs) are capable of unlimited self-renewal in culture while maintaining the potential to differentiate into any cell type present in the human body and thus provide researchers great o

Amyloid β-Peptide (1-42) br Results br Discussion We have su

2018-10-20

Results Discussion We have successfully established a human stem cell model to study the molecular mechanisms underlying MODY5. Our experimental design, which includes a non-family control hiPSC line and three independent hiPSC lines from each of the three subjects in a MODY5 family, is a well

br Results br Discussion In the present

2018-10-20

Results Discussion In the present study we show that LPA1 is expressed by stem and progenitor methylguanine dna methyltransferase (predominantly type 1 and type 2a) within the neurogenic niche of the dentate gyrus of adult mice, and that it outperforms Nestin, the current gold standard, as a

Our analysis revealed that mTOR inhibitors added

2018-10-20

Our analysis revealed that mTOR inhibitors added alone to SF-defined medium can induce mesendoderm, and our follow-up studies confirmed that rapamycin enhances the formation of HE and blood progenitors. Ten-point dose curves revealed a bimodal effect where rapamycin at low concentrations mildly enha

Results br Discussion Expansion of the NP population is thou

2018-10-20

Results Discussion Expansion of the NP population is thought to have contributed to the dramatic increase in the surface area of the neocortex (or neocorticalization) observed in higher mammals (Kriegstein et al., 2006; Rakic, 2009; Sun and Hevner, 2014). Thus, maintenance of the NP pool size an

mSSCs can be maintained and genetically manipulated

2018-10-20

mSSCs can be maintained and genetically manipulated in vitro over extensive periods, providing a valuable resource for in vitro studies of meiosis and post-meiotic development (Kanatsu-Shinohara et al., 2003; Kubota et al., 2004). In the past decade, this culture system has been used to identify key

egfr inhibitors Our behavioral work showed that the aPKC CBP

2018-10-20

Our behavioral work showed that the aPKC-CBP pathway is required for hippocampal-dependent fear memory formation in mature adult mice (6 months old) but not young adult mice (3 months old). This observation correlates well with the age-dependent functions of the aPKC-CBP pathway in maintaining hippo

Hello world!

2018-07-29