• In earlier experiments on snails

  2023-03-28

  

  In earlier experiments on snails, a behavioral model was employed of certain food rejection to study the mechanisms of the reconsolidation of long-term associative memory. It was found that conditioned food stimuli (reminder) presentation, combined with injections of NMDA glutamate receptor antagoni

• Our results suggest that plasma membrane and

  2023-03-27

  

  Our results suggest that plasma membrane and a3-containing V-ATPases represent an important and novel target in the development of drugs to limit breast cancer metastasis. That knock-down of a3 has been shown to reduce metastasis of melanoma cells in an in vivo mouse model suggests that this role ma

• br Colorectal carcinoma The growth rate of murine colon aden

  2023-03-27

  

  Colorectal carcinoma The growth rate of murine colon adenocarcinoma tumors decreased upon inhibition of 5-LOX, an enzyme that harbors counteracting properties to 15-LOX [28]. It is not clear whether 15-LOX was associated with this phenomenon, but its expression is induced in the colon carcinoma c

• Previous studies have indicated that maximal IL protein expr

  2023-03-25

  

  Previous studies have indicated that maximal IL-8 protein Flavin adenine dinucleotide requires NF-κB activation as well as the activation of the MAP kinases ERK, JNK, and p38 (Li et al., 2002). In our study, NF-κB inhibitor can reduce the up-regulated IL-8 production by PRRSV infection, indicating t

• Although the interactions of PhLP with

  2023-03-25

  

  Although the interactions of PhLP with Gβγ and its other partners have been convincingly documented through in vitro studies, it is not clear how PhLP controls flavin adenine dinucleotide signaling in vivo. C. elegans provides a powerful genetic model to analyze Phosducin function and study its int

• br Introduction It is well known that when epithelial cells

  2023-03-22

  

  Introduction It is well known that when epithelial cells are deprived of anchorage, they undergo detachment-induced apoptosis, also known as anoikis. Cancer cells, by contrast, are able to suppress anoikis and survive under anchorage -independent conditions in the circulating system, which is tho

• Another issue is that the vast majority of data from

  2023-03-22

  

  Another issue is that the vast majority of data from PET and CSF are from selected participants recruited through tertiary care dementia centers [176]. It is widely recognized that clinic-based participants differ from community-based studies, for example, the amount, type, and distribution of neuro

• br Results and discussion br Conclusion The tyrosine kinase

  2023-03-22

  

  Results and discussion Conclusion The tyrosine kinase ALK represents one of the most successful molecular targets for the development of precise medicine to treat stratified subgroups of cancer patients. Three generations of ALK inhibitors have been awarded the FDA's approval or are being exte

• The present work has implications for

  2023-03-22

  

  The present work has implications for our thinking about the effects of antidepressant (e.g. SSRIs) use on maternal care in depressed mothers which consist of approximately 10–20% of all mothers (Gjerdingen and Yawn, 2007, Susser et al., 2016), and more than 40% of depressed mothers are prescribed w

• Most studies on d penicillamine

  2023-03-22

  

  Most studies on d-penicillamine-induced MG were performed before the discovery that some MG patients have anti-MuSK antibodies. After the identification of the present case, we retrospectively tested the stored frozen sera of ten earlier identified d-penicillamine MG patients with anti-AChR gstp1-1

• For some fishstocks landed by FMA ACE fishers the

  2023-03-22

  

  For some fishstocks landed by FMA3 ACE fishers, the designated Quota Management Area (QMA) extends beyond the geographic demarcations of FMA3.Fig. 1 shows the ten FMAs, highlighting the study area FMA3. Gurnard 3 QMA is included as an example of a QMA that Cinacalcet extends across more than one FM

• br Funding This work was supported by Arena Pharmaceuticals

  2023-03-22

  

  Funding This work was supported by Arena Pharmaceuticals, Inc, San Diego, CA, USA. Introduction 5-hydroxytryptamine 1B (5-HT1B) receptors are widely distributed in the central nervous system (CNS); they have various modulatory functions in drug reinforcement, appetitive behaviors, stress, moo

• Introduction hydroxytryptamine HT is found throughout the

  2023-03-22

  

  Introduction 5-hydroxytryptamine (5-HT) is found throughout the body and influences smooth muscle activity in various tissues including the intestine, vasculature and urinary Vilazodone Hydrochloride (Kim and Camilleri, 2000, Klarskov and Horby-Petersen, 1986, Mohammad-Zadeh et al., 2008). The cur

• br Materials and methods br Results br Discussion

  2023-03-22

  

  Materials and methods Results Discussion The success of CAR-T cell therapy is based on two major facts: one is that cancer cells express tumor-associated antigens (TAAs) on their surface that can be detected by the human immune system; the other is that the CAR molecules target these TAAs o

• Skeletal pain associated with bone fracture is

  2023-03-22

  

  Skeletal pain associated with bone fracture is another area of critical need for a novel pain medication. NSAIDs and opiates are the two major therapies currently used to manage bone fracture pain. However, both of these therapies lead to significant unwanted side effects. Using the osteotomy model

15120 records 271/1008 page Previous Next First page 上5页 271272273274275 下5页 Last page