• G protein coupled receptor GPCR ligands

  2022-07-26

  

  G-protein-coupled receptor (GPCR) ligands can be classified as either orthosteric or allosteric modulators. Orthosteric and endogenous ligands bind to the same site, which is topologically distinct from the allosteric site. In general, the binding domains of different orthosteric ligands may not exa

• Variants of NEIL were also analysed in

  2022-07-26

  

  Variants of NEIL1 were also analysed in Primary sclerosing cholangitis (PSC) and cholangiocarcinoma (CCA) patients by Forsbring et al. to identify effect of variants on these diseases. Four variants were identified i.e., one earlier validated (G83D) and three novel (E181K, H275, R339W). E181K was fo

• The simple carrier model for GLUT transport activity propose

  2022-07-25

  

  The simple carrier model for GLUT1 transport activity proposes that the transporter alternates between an outward facing glucose binding site and an inward, cytoplasmic, facing glucose binding site. Cytochalasin B is an endofacial inhibitor and appears to preferentially bind to the open, inward faci

• Introduction The Hedgehog Hh signaling pathway regulates emb

  2022-07-25

  

  Introduction The Hedgehog (Hh) signaling pathway regulates embryonic organogenesis, tissue patterning, and cell differentiation (Armas-Lopez et al., 2017, Ingham and McMahon, 2013). Aberrant activation of Hh signaling pathway contributes to tumor formation and development of various cancers includi

• HBX 41108 br Methods br Results br Discussion

  2022-07-25

  

  Methods Results Discussion In this series of studies we hypothesized that FHH-GHSRm1/Mcwi rats would, relative to their WT counterparts, exhibit a metabolic and behavioral phenotype reminiscent of GHSR−/− mice. Through the use of the GHSR−/− mouse, a great deal about the role of ghrelin sig

• br Histamine H R The cloning of the H R

  2022-07-22

  

  Histamine H4R The cloning of the H3R (Lovenberg et al., 1999) provided a template for the search of other Cell Cycle Compound Library receptors, and resulted in the most recent discovery of histamine H4R. This concluded with six independent groups that have reported the cloning of the H4R (Leurs

• br Parkinson disease Idiopathic PD is a hypodopaminergic mov

  2022-07-22

  

  Parkinson disease Idiopathic PD is a hypodopaminergic movement disorder of uncertain etiology that affects 3% of persons over age 65 (Dexter and Jenner, 2013). Cardinal signs of this common neurodegenerative condition include bradykinesia, rigidity, rest tremor and postural instability. Autonomic

• br Methods br Involvement of HO in rheumatic diseases

  2022-07-22

  

  Methods Involvement of HO-1 in rheumatic diseases Therapeutic strategy targeted HO-1 Based on the researches focusing on the effect of HO-1 in rheumatic diseases, amount of approaches targeting regulation of HO-1 have been arising (See Table 1 for summary). It has been shown that different

• There are several limitations in our study First only the

  2022-07-22

  

  There are several limitations in our study. First, only the naturally occurring resistance-associated mutations in patients coinfected with HIV/HCV TAK-715 1b were analyzed. The result was only applicable to HCV genotype 1b, but not the HCV genotype 1a patients. We did not analyze the effect of geno

• Using RT PCR we demonstrated the expression of GPR receptor

  2022-07-21

  

  Using RT-PCR we demonstrated the expression of GPR55 receptor mRNA in the ileum and colon of mice, which is in good agreement with previous reports (Lin et al., 2011). The quantitative analysis showed the abundance of GPR55 mRNA in the mucosa of the ileum and colon. In contrast, in LMMP preparations

• To apply the recently developed GPR ligands to

  2022-07-21

  

  To apply the recently developed GPR35 ligands to CNS disorders, it is necessary to understand whether GPR35 is expressed by any identified cell types in the EPZ031686 and whether activation or blockade of this receptor has any consequence on the activity of the neuronal circuitry. To this end, the

• br Methods br Results br Discussion LPD in terms of

  2022-07-21

  

  Methods Results Discussion LPD, in terms of insufficient secretion of progesterone by the CL, reflected by low serum progesterone levels can occur in IVF attempts using any kind of ovarian stimulation protocol (Fatemi et al., 2007, Garcia et al., 1981, Van der Linden et al., 2011). However,

• Previous studies have shown that zinc interacts with other

  2022-07-21

  

  Previous studies have shown that zinc interacts with other allosteric modulators at the glycine receptor (Kirson et al., 2013, McCracken et al., 2010, McCracken et al., 2013). Of note, the chelation of zinc via tricine decreases the effects of alcohol at α1-, α2-, and α3-containing glycine receptors

• Much less is known about the and subunits

  2022-07-21

  

  Much less is known about the α3 and α4 subunits. GlyR α3 subunit immunoreactive synapses are concentrated in discrete bands across the IPL; besides, bipolar, amacrine and ganglion cells have been suggested to express it (Haverkamp et al., 2003, Wässle et al., 2009). In fact, All amacrine express α3

• Here we report the first attempts

  2022-07-21

  

  Here we report the first attempts to assess roles of NTs and ABC transporters in transfer of ribavirin across the placental barrier using human placental villous fragments and microvillous plasma membrane (MVM) vesicles, in situ dually perfused rat term placenta, and cell-based models. Materials

15773 records 387/1052 page Previous Next First page 上5页 386387388389390 下5页 Last page