• br Results br Discussion ER and GR play

  2022-02-18

  

  Results Discussion ER and GR play opposite phenotypic roles in the normal endometrium, with ER promoting growth and GR inhibiting growth. Here, we show that in endometrial cancer, GR expression is associated with worse outcomes and higher-grade tumors, and this association is observed only in

• br In vivo actions of GLP GLP R agonists

  2022-02-18

  

  In vivo actions of GLP-1/GLP-1R agonists on the vascular endothelium Using contrast-enhanced ultrasound, male Sprague Dawley rats receiving an intravenous infusion of native GLP-1 (30 pmol/kg/min) for 2 h demonstrated significant improvements in both microvascular blood volume and microvascular b

• br Materials and methods br Results br Discussion

  2022-02-18

  

  Materials and methods Results Discussion The current study validates a key role for GAL3 receptors in consummatory drive for sucrose, saccharin, and most notably ethanol intake in mice. We show that alcohol preferring mice drink less ethanol compared to wildtype mice when treated with the G

• Our results are consistent with the hypothesis that reduced

  2022-02-18

  

  Our results are consistent with the hypothesis that reduced Fas-mediated apoptosis in maternally activated T-lymphocytes could result in insufficient trophoblast invasion of the spiral FAK Inhibitor 14 as the activated T-lymphocytes become able to enhance the destruction of the cytotrophoblasts. A r

• The ability of the vasculature to determine

  2022-02-18

  

  The ability of the vasculature to determine the nature and magnitude of a stimulus is essential for the appropriate and proportionate response. The vascular response to injury include rapid changes to blood flow to reduce the loss of blood, followed by increased contact with the sub-endothelial laye

• br Application of TIRFM to visualizing exocytosis TIRFM was

  2022-02-18

  

  Application of TIRFM to visualizing exocytosis TIRFM was first used to visualize exocytosis from large secretory granules from chromaffin Fer-1 (Steyer et al., 1997). Before that, visualization of secretory organelle was strictly limited to a few exceptions, such as mast cell of mutant mice, or

• SCH is a H R receptor antagonist introduced by Schering

  2022-02-18

  

  SCH-497079 is a H3R receptor antagonist introduced by Schering-Plough, without any publicized pharmacological and structural information. A Phase II clinical trial assessment of SCH-497079 on weight has been completed in a multicenter, randomized, parallel-group and placebo-controlled study in obese

• br Conclusion br Acknowledgements This study was supported b

  2022-02-18

  

  Conclusion Acknowledgements This study was supported by the China Postdoctoral Science Foundation (No.2015M581817), the National Research Council of Science and Technology Support Program (2015BAD03B05-06), and the Priority Academic Program Development of Jiangsu Higher Education Institutions

• br Acknowledgement The work was supported by the NSFC throug

  2022-02-18

  

  6. Acknowledgement The work was supported by the NSFC through Grant Nos. 11535016 and 11475232. It was also supported by CAS. The authors thank their collaborators for beneficial discussions and enthusiastic supports in the simulations and calculations. Introduction Hypoxia-inducible factors

• In addition to acting as the gatekeeper

  2022-02-17

  

  In addition to acting as the gatekeeper for the metabolic and antioxidant roles of glucose, HKs have also been found to regulate mPTP opening directly. First described in the cancer field, the high-affinity HK isoforms HK1 and HK2 are strongly anti-apoptotic when bound to the outer mitochondrial mem

• A few animal and cell culture studies

  2022-02-17

  

  A few animal and cell culture studies have been reported that the reason of HCV-related hepatic steatosis in CHC infection is mainly HCV core protein (Chang et al., 2007; Perlemuter et al., 2002; Ferré, 2004). HCV core protein inhibits activities of microsomal triglyceride transfer protein (MTP) and

• Currently the computational chemical biology

  2022-02-17

  

  Currently, the computational chemical biology has been applied in hepatitis B antiviral drug discovery research [18]. Tan et al. explored oxime ethers as HBV inhibitors by docking and screening [19]. Allen et al. clarified the resistance of HBV to the nucleoside drug lamivudine [20]. The results sug

• In comparing the amounts of total

  2022-02-17

  

  In comparing the amounts of total GST activity of the rabbit cornea, porcine cornea and Hemicornea construct (Fig. 4A), the construct was found to exhibit an obviously lower level of GST activity. To assess these findings, it molar weight calculator will be necessary to compare them to the level in

• Sepsis was defined as a systemic inflammatory response

  2022-02-17

  

  Sepsis was defined as a systemic inflammatory response syndrome (SIRS) associated with severe infection in 1992 [9]. However, in the Third International Consensus Definitions for Sepsis and Septic Shock [10], it was redefined as life-threatening organ dysfunction provoked by a dysregulated host resp

• To test our refinement protocol we considered a benchmark

  2022-02-17

  

  To test our refinement protocol, we considered a benchmark set of 12 N-linked glycan-containing protein structures determined by X-ray crystallography at resolutions ranging between 1.9 Å and 3.5 Å and comprising a total of 133 glycan units. We identified four incorrect anomeric configurations and 2

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