• Several studies have found that

  2021-11-16

  

  Several studies have found that GPR55 possesses a distinct pharmacology from that of CB1 and CB2, and that only certain cannabinoids act at this receptor. In transfected Phosphoramidon Disodium Salt expressing hGPR55, out of more than 20 synthetic and endogenous cannabinoids evaluated, only 2 compou

• Peripheral injury or disease induced alterations in synaptic

  2021-11-16

  

  Peripheral injury- or disease-induced alterations in synaptic efficacy occur not only at the first synapse made by the primary nociceptive afferents in the spinal dorsal horn but are also operational in several regions processing the sensorimotor as well as emotional-affective components of pain, su

• br Material and methods br Results and discussion br Discuss

  2021-11-16

  

  Material and methods Results and discussion Discussion It is well established that the guanosine-rich DNA sequences within telomeric DNA repeats, and in the promoter regions of a number of oncogenes or proto-oncogenes such as c-myc [20,23], VEGF [28,48,49] and Bcl-2 [21,50], can readily ass

• G quadruplex structures can be resolved by helicases Consist

  2021-11-16

  

  G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer Cariprazine [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and discovered tha

• br Ethics approval br Availability of data and

  2021-11-16

  

  Ethics approval Availability of data and materials Consent for publication Competing interests Authors contributions Introduction Glucose supply to tissues is maintained through a complex regulatory network mostly driven by the pancreatic hormones insulin and glucagon which control

• In addition JMJ proteins respond

  2021-11-16

  

  In addition, JMJ proteins respond to biotic stress and abiotic stress in plants. Rice genes OsJMJ704 and OsJMJ705, which have demethylase activities of H3K27me2/3 and H3K4me2/3, respectively, regulate defense-related genes and affect the defense ability of rice against bacterial pathogen Xoo (Li et

• br Discussion The aim of the present study was

  2021-11-16

  

  Discussion The aim of the present study was to extend the list of ASIC ligands and to check if histamine receptors ligands can also affect ASICs. The novel finding is that not only histamine but also thioperamide, 1-metylhistamine and Nα-methylhistamine are active ASIC1a potentiators, while other

• br Methods br Acknowledgements We are

  2021-11-16

  

  Methods Acknowledgements We are grateful to Eric Olson for providing Yap/Taz floxed mice, and to members of the Epstein lab for helpful comments and advice. This work was supported by NIH R01 HL118768, R35 HL140018, the Cotswold Foundation and the WW Smith Endowed Chair to J.A.E. The Hippo

• P Benzoxaborole substituted macrocyclic compounds based on I

  2021-11-16

  

  P4-Benzoxaborole-substituted macrocyclic compounds based on ITMN-191 scaffold were prepared using a general scheme as shown in . ITMN-191 was prepared by following a patent procedure. The P4 BOC group was removed by treatment with TFA in dichloromethane to give amine . The coupling of the amine to 6

• Acknowledgments The authors thank Partners Healthcare

  2021-11-15

  

  Acknowledgments The authors thank Partners Healthcare for financial support. This work was also supported in part by NIH Grant R01CA122608 to J.M.G.H. Introduction The phosphorylation of histone H3 is recognized as a hallmark of mitosis. Histone H3 phosphorylation at Thr3 (H3T3ph) acts as a mit

• Introduction Inorganic arsenic InAs species such as arsenite

  2021-11-15

  

  Introduction Inorganic arsenic (InAs) species such as arsenite (AsIII) and arsenate (AsV) are present in groundwater. Arsenic contaminated drinking water is a global public health issue because of its natural prevalence and toxicity. Long exposure to arsenic results in chronic effect in humans, inc

• GCIPs are highly conserved Ca binding proteins first

  2021-11-15

  

  GCIPs are highly conserved Ca2+-binding proteins first discovered in the frog [42] and later in teleost [9]. With regard to gene structure, sequence conservation, and function, GCIPs are evolutionarily related to the GCAPs. The GCIP genes have acquired an additional intron in the N-terminal region w

• The primary requirements of an ideal bioprobe for

  2021-11-15

  

  The primary requirements of an ideal bioprobe for glucose transporter-mediated bioimaging include high specificity, sensitivity as well as low cytotoxicity [18]. According to these concepts, we recently reported the simple amide linked glycoconjugates which containing cyanine fluorophores (Cy3 and C

• To identify inhibitors of the Hh GLI signaling pathway

  2021-11-15

  

  To identify inhibitors of the Hh/GLI signaling pathway from natural resources, we have recently reported the successful construction of a cell-based screening assay system for the Hh/GLI signaling pathway (Fig. 1). This is an assay using a GLI-dependent luciferase reporter in human keratinocyte cell

• br Discussion br Author Contributions br Alzheimer s disease

  2021-11-15

  

  Discussion Author Contributions Alzheimer’s disease (AD) is an age-related, chronically progressive neurodegenerative disorder affecting more than 35million people worldwide and an estimated 5.5million in the US. Current marketed drugs such as acetylcholinesterase inhibitors and the NMDA ant

15826 records 532/1056 page Previous Next First page 上5页 531532533534535 下5页 Last page