• The following are the supplementary data related to this

  2021-01-19

  

  The following are the supplementary data related to this article. Acknowledgments Introduction Drug-resistant epilepsy (DRE) occurs in approximate 30% of patients who suffer from epilepsy [1]. Temporal lobe epilepsy (TLE) is one of the most common partial seizures and the common cause of DRE

• Immunofluorescence Cells were fixed with paraformaldehyde PF

  2021-01-19

  

  Immunofluorescence. Cells were fixed with 4% paraformaldehyde (PFA) in PBS and extracted by 0.5% Triton X-100-PBS, or fixed in cold methanol. The cells were immunostained with mouse monoclonal bcl-2 inhibitor against α-tubulin (Sigma), γ-tubulin (Sigma), Ran (Upstate), rabbit polyclonal antibodies

• Data from our in vitro

  2021-01-19

  

  Data from our in vitro studies using BEAS-2B cells showed a biphasic response of cells to NNK. The initial phase of decrease in CRM1 expression in NNK-exposed cells was observed in our previous study. In this study, we further showed that p-p53 (Thr55) expression was also decreased during this initi

• KU-55933 Several lines of evidence suggest that the anxiety

  2021-01-19

  

  Several lines of evidence suggest that the anxiety provoking behavioral effects of CRF involve CRF1 receptors. CRF1 knockout mice show increased anxiolytic-like activity in the elevated plus maze and a tendency to enter the illuminated region of a light–dark box [49], [52]. In addition, studies usin

• Caspi et al first identified that the COMT polymorphism

  2021-01-19

  

  Caspi et al. (2005) first identified that the COMT polymorphism moderated the influence of adolescent cannabis use on developing adult psychosis (Caspi et al., 2005). In particular, compared to Met carriers, subjects with the Val/Val genotype were most likely to exhibit psychotic symptoms and to dev

• No effect on the A production

  2021-01-19

  

  No effect on the Aβ production by γ-secretase was observed at 50μM, the highest effective concentration used in cultured THZ1 by the study of Flajolet et al. IC261 did also not exert a modulatory effect on the production of Aβ, Aβ and Aβ species in the cell-free assay at this concentration. γ-Secre

• In silico modelling studies might aid

  2021-01-19

  

  In silico modelling studies might aid our understanding of the functionality and potential biological activity of food and, in the long-term they might underpin the development of personalised diets to reduce health risks and help us to better understand pharmaceutical/food interactions. Acknowle

• ERR is present early in the developing placenta in

  2021-01-19

  

  ERRβ is present early in the developing placenta in a subset of BD 1047 dihydrobromide in extra-embryonic ectoderm destined to make up the chorion.19, 20 ERRβ is likely essential for reproduction. ERRβ expression is essential for the maintenance of pluripotency and self-renewal potential in mouse e

• EP EP and EP receptor expression on HMVEC L

  2021-01-19

  

  EP1, EP3 and EP4 receptor expression on HMVEC-L was shown recently by flow cytometry [14]. However, only EP4 mRNA expression was previously described in these cells [49]. Our data obtained with RT-PCR showed EP4 mRNA and very low levels of EP1 mRNA, but no EP2 and EP3 mRNA expression was detectable

• Adding more pieces to the puzzle using a human to

  2021-01-19

  

  Adding more pieces to the puzzle, using a human-to-animal crossover study, blood taken from healthy volunteers that underwent exercise was used as a dialysate to perfuse a rabbit heart in a Langendorff model of MI [62]. Unprecedentedly, dialysate of plasma from exercised humans reduced infarct size

• DHEA Introduction Obesity constitutes a global healthcare pr

  2021-01-19

  

  Introduction Obesity constitutes a global healthcare problem and has many adverse effects on the cardiovascular function [1,2]. Recently, the perivascular adipose tissue (PVAT) has emerged as a relevant fat depot for cardiovascular risk and as a potential trigger in vascular dysfunction. Indeed, PV

• Metal ions are known not to be

  2021-01-19

  

  Metal ions are known not to be necessary for catalytic activity of serine proteinases. Nevertheless, Co2+ and Ca2+ ions were found to stabilize glutamyl endopeptidase molecule [1], [7], [19]. In our previous study, we have described significant stimulating effect of Ca2+, Mg2+, and Co2+ on biosynthe

• cetylpyridinium The yeast Rad p radiation sensitive also cal

  2021-01-19

  

  The yeast Rad6p (radiation sensitive 6, also called Ubc2) E2 ubiquitin-conjugating enzyme is a member of the highly conserved UBC proteins in eukaryotes (Xu et al., 2009). Rad6p is involved in several cellular processes, including DNA repair, transcriptional activation and silencing, histone ubiquit

• br Materials and methods br

  2021-01-19

  

  Materials and methods Results Discussion Drug of abuse induces widespread ll-37 changes in the molecular and cellular functions in circuits between VTA and its neighbored regions such as NAC, and amygdala. It is belived that these changes result behavioral phenotype that characterize addic

• br Materials methods br Results br Discussion As shown by

  2021-01-19

  

  Materials & methods Results Discussion As shown by qPCR analysis, Bdnf1 expression was up-regulated by approximately fifty percent after injection of RG108. A possible explanation is that the overall methylation in promoter of exon I is decreased by the compound, therefore facilitating its

15126 records 657/1009 page Previous Next First page 上5页 656657658659660 下5页 Last page