• will be remembered as an exceptional year

  2019-06-13

  

  2013 will be remembered as an exceptional year in shaping our strategy to control HIV/AIDS. Indeed, a few weeks after the 30th anniversary of the discovery of the virus, a decisive step was made in deciding how to use antiretroviral therapy (ART) for treatment and prevention worldwide. New WHO publi

• br Discussion Chronic myelogenous leukemia CML is

  2019-06-13

  

  Discussion Chronic myelogenous leukemia (CML) is a clonal disorder involving the pluripotent stem cell and is consistently associated with the BCR-ABL1 fusion gene located on the Philadelphia chromosome [1]. The disease typically evolves in 3 distinct clinical stages: chronic and accelerated phas

• The importance of social determinants on population health i

  2019-06-13

  

  The importance of social determinants on population health is widely known. Beyond this recognition, key questions that still need to be addressed include research into how to best address social determinants through intersectoral collaboration. Pillay-van Wyk and colleagues identify this approach a

• br Demographic and arrhythmia characteristics gender circadi

  2019-06-12

  

  Demographic and arrhythmia characteristics: gender, circadian pattern of VF, and atrial arrhythmias The prevalence and arrhythmic risk of BS and ERS differ considerably. The BS ECG pattern occurs rarely in the general population, while the ER pattern is a common ECG phenomenon, especially in youn

• Univariate analysis for overall survival revealed that age y

  2019-06-12

  

  Univariate analysis for overall survival revealed that age (≤, >50 years), menopausal status, T-N stage, and histological tumor size were statistically significant factors for survival. Menopausal status was determined after two years of amenorrhea. In post-menopausal women, the disease-free surviva

• RANK RANKL The RANK RANKL signaling

  2019-06-12

  

  RANK/RANKL: The RANK/RANKL signaling pathway is a critical component of both normal and malignant bone remodeling. RANK is a transmembrane signaling receptor and a member of the tumor necrosis receptor (TNF) superfamily that is found on the surface of OCL precursors [43,44]. RANK ligand (RANKL) is e

• Sulindac sulfide We established Wt and two Mt p

  2019-06-12

  

  We established Wt- and two Mt- (p.R308P and p.A350_N351ins8)-GATA2-expressing 32D Sulindac sulfide to analyze the cellular effects of Mt-GATA2 (Fig. 3A). Immunofluorescence analysis revealed that Mt-GATA2 showed similar localization in the nucleus as Wt-GATA2 (Fig. 3B). Both Wt- and mutant-GATA2-ex

• An interesting finding in the study of Ngabo

  2019-06-12

  

  An interesting finding in the study of Ngabo and colleagues was that, after a huge drop in the number of admittances to hospital for rotavirus in 2013, there was no further fall the next year. As the researchers discuss, this finding might herald the beginning of a biennial pattern of rotavirus acti

• br Conclusion br Funding br Conflict

  2019-06-12

  

  Conclusion Funding Conflict of interest Introduction Over the last decade, the unabated increase in the number of transseptal catheterizations has been related to an increase in atrial fibrillation (AF) ablation procedures. Transseptal puncture (TP) is usually safe in experienced hands [

• Common and rare SCN A variants may contribute to

  2019-06-12

  

  Common and rare SCN10A variants may contribute to AF susceptibility [59,60]. SCN10A mutations (R14L and R1268Q) cause a loss of function of Nav1.5 current, which is expected to reduce excitability and lead to the development of the arrhythmogenic substrate responsible for BrS and AF. A common varian

• El cap tulo sobre de Jos Agust

  2019-06-12

  

  El capítulo sobre de José Agustín expone las diferencias entre el de Agustín, de 1966, y el de Pacheco, de 1972. Lo que tienen en común ambas obras, aclara el crítico, es que —a diferencia de otras estudiadas en el volumen— no atestiguan momentos de crisis sino “los largos entretiempos que precede

• Findings from the last major systematic

  2019-06-12

  

  Findings from the last major systematic review of the global prevalence of echocardiographic rheumatic Purmorphamine disease showed that the highest calculated regional prevalence was in sub-Saharan Africa (5·7 cases per 1000 people), indigenous people in the Pacific islands, Australia, and New Zea

• Introduction Atrial fibrillation AF is the

  2019-06-11

  

  Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice. The number of people with AF in the United States is currently estimated at 2.4 million, and the projected number with AF may exceed 10 million by 2050 [1,2]. Treatment for AF is also an im

• br Sensors for HF monitoring

  2019-06-11

  

  Sensors for HF monitoring can be classified according to the technical instrumentation. Table 2 summarizes the sensors that have been used or proposed to monitor the events of HF. The paced QRS enables the determination of the QT duration. In addition, the QRS width, measured as the ventricular de

• br Interpretation of identified genetic variants

  2019-06-11

  

  Interpretation of identified genetic variants and genetic counseling Although the current expert consensus statement recommends that comprehensive or BrS1 (SCN5A) targeted BrS genetic testing can be useful for genetic testing [63], not all the published SCN5A mutations in BrS have been subjected

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