• Among the AXL positive tumors that we screened the TNBC

  2024-06-17

  

  Among the AXL-positive tumors that we screened, the TNBC cell line MDA-MB-231 showed the highest AXL expression level. Additionally, AXL protein levels were higher in TNBC patient samples than in other breast cancers. Considering the difficulty of, and the urgent need for, effective treatments of TN

• In pancreatic islets we found an increase

  2024-06-17

  

  In pancreatic islets we found an increase in protein expression of leukocyte 12/15-LO that paralleled the metabolic decline characterized by severe hyperglycemia and reduced islet numbers. Similar increase in 12/15-LO expression by Western blot was found in the control mice, which have a normal meta

• br Apelin Discovered in apelin was initially

  2024-06-17

  

  Apelin Discovered in 1998, apelin was initially identified as the sole endogenous ligand for the APJ receptor (Tatemoto et al., 1998). Apelin-77 (pre-pro-apelin) is the precursor for various pharmacologically active apelin isoforms (e.g. apelin-12, -13, -17 and 36), and it shares 75–95% sequence

• Although the earlier studies focused on the antioxidant capa

  2024-06-17

  

  Although the earlier studies focused on the antioxidant capacity of tocopherols, ascorbic 3576 and carotenoids, then it was noticed that phenolic compounds were more powerful than others (Rice-Evans, Miller, & Paganga, 1996). Phenolic compounds, the most numerous and ubiquitous groups of plant secon

• Since artemisinin shows low solubility and poor

  2024-06-17

  

  Since artemisinin shows low solubility and poor oral bioavailability [8], [9], derivatizations of artemisinin were carried out and yielded different semisynthetic antimalarial drugs such as artemether and sodium artesunate. Artemether (decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano [4.3-

• br Methods for antifungal testing

  2024-06-17

  

  Methods for antifungal testing of mucorales species The Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST) reference methods currently in place for in vitro antifungal susceptibility testing of filamentous fungi [8], [9] have

• Other reports however have indicated that all components of

  2024-06-17

  

  Other reports, however, have indicated that all components of RAS are produced within the central nervous system (CNS) (Saavedra, 2005). Thus, AGTR1 and AGTR2 in circumventricular organs and in cerebrovascular endothelial cells may respond to circulating ANG2 of peripheral origin, whereas neural rec

• br Competing interests br Acknowledgments

  2024-06-17

  

  Competing interests Acknowledgments This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2014R1A4A1071040). Introduction Mitochondria occupy an important position as mediators of

• br Expression of adiponectin mRNA

  2024-06-14

  

  Expression of adiponectin mRNA in chickens We first sought to determine the nucleotide sequence of the chicken adiponectin cDNA. The open reading frame of the chicken adiponectin cDNA consists of 735 nucleotides that was 65–68% homologous to various mammalian adiponectin cDNAs (Maddineni et al.,

• The literature suggests that adiponectin

  2024-06-14

  

  The literature suggests that adiponectin has a steroidogenic effect on ovarian function. In pigs, in vitro studies have shown that adiponectin reduced basal testosterone secretion in internal theca cells; in granulosa cells, it increased secretion of estradiol and, in combination with insulin, incre

• Active SI behavior was dose dependently affected by PACAP tr

  2024-06-14

  

  Active SI behavior was dose-dependently affected by PACAP treatment (F3,25 = 14.42, p reverse transcriptase inhibitors 1 week later (F3,20 = 8.93, p in the 5CSRTT were dose-dependently produced by PACAP. Effects of PACAP depended on significant dose × day interactions for correct responding (F12,76

• br Funding br Introduction l Dihydroxyphenylalanine

  2024-06-14

  

  Funding Introduction l-3,4-Dihydroxyphenylalanine (l-DOPA) is the gold-standard treatment for the motor symptoms of Parkinson's disease (PD); however, its chronic use induces severe motor complications that eventually limit its long-term efficacy (Bastide et al., 2015). The most disabling side

• MafB a member of the Maf protein family

  2024-06-14

  

  MafB, a member of the Maf protein family, is essential for terminal differentiation of macrophages (Kelly et al., 2000). The phagocytic activity of polystyrene beads was found to be enhanced in Gabapentin with exogenous expression of MafB (Tillmanns et al., 2007). However, in alveolar macrophages of

• Protein protein interaction networks are an

  2024-06-14

  

  Protein–protein interaction networks are an important ingredient for the system-level understanding of cellular processes. Such networks can be used for filtering and assessing functional genomics data and for providing an instinctive platform for annotating structural, functional and evolutionary p

• HMGN proteins are subject to extensive

  2024-06-13

  

  HMGN proteins are subject to extensive post-translational modifications which influence both their mode of binding to Imiquimod hydrochloride and their functional activity. Like the other HMG protein families, HMGNs are substrates for many of the same enzymes that modify histone proteins (review in

15846 records 137/1057 page Previous Next First page 上5页 136137138139140 下5页 Last page